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Reactive Drug Metabolites

Author: Amit S. Kalgutkar
Publisher: John Wiley & Sons
ISBN: 352765576X
Size: 73.38 MB
Format: PDF
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Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizing enzymes that can participate in catalyzing reactive metabolite formation, including a discussion of the structure-toxicity relationships for drugs. Two chapters are dedicated to the currently hot topics of herbal constituents and IADRs. The next part covers current strategies and approaches to evaluate the reactive metabolite potential of new drug candidates, both by predictive and by bioanalytical methods. There then follows an in-depth analysis of the toxicological potential of the top 200 prescription drugs, illustrating the power and the limits of the toxicophore concept, backed by numerous case studies. Finally, a risk-benefi t approach to managing the toxicity risk of reactive metabolite-prone drugs is presented. Since the authors carefully develop the knowledge needed, from fundamental considerations to current industry standards, no degree in pharmacology is required to read this book, making it perfect for medicinal chemists without in-depth pharmacology training.

Nutrition And Lifestyle In Neurological Autoimmune Diseases

Author: Ronald Ross Watson
Publisher: Academic Press
ISBN: 0128054441
Size: 11.49 MB
Format: PDF, ePub
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Nutrition and Lifestyle in Neurological Autoimmune Diseases: Multiple Sclerosis discusses important discoveries relating to the types of, and efficacy of, nutritional and lifestyle responses to symptoms and reoccurrence of MS. Each chapter defines a new approach to use in foods, dietary supplements, exercise, behavior, and/or lifestyle in health promotion and symptoms management for MS. This book presents the role of non-pharmaceutical approaches and is essential reading for neurologists, physicians, nurses, nutritionists, dietitians, healthcare professionals, research scientists, biochemists, and general practitioners. Presents a comprehensive overview that details the role of nutrition and exercise in Multiple Sclerosis Written for researchers and clinicians in neurology, neuroscience, and exercise and nutrition Defines a new approach that focuses on foods, dietary supplements, exercise, behavior, and lifestyle in health promotion and symptoms management for MS

Photosensitisation

Author: Giuliana Moreno
Publisher: Springer Science & Business Media
ISBN: 3642731511
Size: 62.23 MB
Format: PDF, ePub, Docs
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Radiation induces a variety of chemical processes in biological tissues. This volume is a synthesis of up-to-the-minute reviews on such photochemical and photobiological sensitized reactions with particular relevance to photomedicine. The first part gives a description of experimental techniques for the study of the primary processes after radiation absorption by biological systems. It is followed by chapters on singlet oxygen and photomedicine, considering both phototherapy and photochemotherapy. These sections also discuss the next generation of potential photosensitizing drugs.

Hospice And Palliative Care For Companion Animals

Author: Amir Shanan
Publisher: John Wiley & Sons
ISBN: 1119036658
Size: 24.63 MB
Format: PDF
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Hospice and Palliative Care for Companion Animals: Principles and Practice offers the first comprehensive reference to veterinary hospice and palliative care, with practical guidance and best practices for caring for sick and dying animals. Presents the first thorough resource to providing veterinary hospice and palliative care Offers practical guidance and best practices for caring for sick and dying animals Provides an interdisciplinary team approach, from a variety of different perspectives Gives concrete advice for easing pets more gently through their final stage of life Includes access to a companion website with client education handouts to use in practice

Photobiology In Medicine

Author: Giulo Jori
Publisher: Springer Science & Business Media
ISBN: 1489913130
Size: 28.18 MB
Format: PDF, Kindle
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Man has recognised an association of light with life and medicine for over 3000 years. Today the major challenges to this topic include the elucidation of photochemical reactions involved in photobiology at the molecular level. This includes the use of a variety of modem probing techniques that directly measures the reactivity of excited states and free radicals involved in biological reactions. This text-book is based on such an approach and has arisen from some of the lectures delivered at the NATO ASI held at Hotel Capo Caccia near the Centre for Advanced Research in Photobiology (CARP) in Sardegia, Italy. The ASI took place from 30 September -13 October 1993 and involved a total membership of 90. The book, like the NATO ASI itself, is divided into four themes starting with fundamental aspects and ending with complex medically related systems. Thus Theme 1 covers aspects of the underlying photophysics and photochemistry with particular emphasis on modem experimental techniques to study molecular mechanisms of biological processes. Theme 2 applies many of these fundamental studies to the chemical reactions of most relevance to photobiology and photomedicine such as photo-addition, -isomerization, -sensitization and -pigmentation. The third and fourth Themes deal with the deleterious and therapeutic aspects of light with particular emphasis on the use of Photo-Dynamic Therapy (PDT) to treat cancer and on viral and micro bioi infections.

The Science Of Photomedicine

Author: J.D. Regan
Publisher: Springer Science & Business Media
ISBN: 1468483129
Size: 43.83 MB
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Although the history of photomedicine dates back thousands of years, with even preliterate cultures appreciating the healing properties of sunlight, for many workers in the discipline photomedicine is associated with the observation about 100 years ago of Niels Finsen, a Danish physician. Finsen recognized that people with tuberculosis who lived in Norway and who had very little exposure to sunlight often developed facial lesions (lupus vulgaris) which would decrease and sometimes disappear during the summer months. This very observant physician reasoned that artificial light ought to produce the same effect as sunlight and began utilizing the radiation from the newly available carbon arc. At first, he used a glass lens to concentrate the radiation, but since this produced considerable burning, he replaced this with a hollow glass lens filled with water. However, while this reduced the heat burns, it did not actually duplicate the effect of direct sunlight. Finally, using a hollow lens filled with water but equipped with quartz windows, Finsen was able to imitate, even improve upon, the effect of sunlight. As a result, lupus vulgaris was practically eliminated from the Scandinavian countries.

Metabolic Phenotyping In Personalized And Public Healthcare

Author: Jeremy Nicholson
Publisher: Academic Press
ISBN: 0128004142
Size: 80.62 MB
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Metabolic Phenotyping in Personalized and Public Healthcare provides information on the widespread recognition that a personalized or stratified approach to patient treatment may offer a more efficient and effective healthcare solution than phenotype-led approaches. In order to achieve that objective, a deep personal description is required at the level of the genome, proteome, metabolome, or preferably a combination of these aided by technology. This book, edited and written by the outstanding luminaries of this evolving field, evaluates metabolic profiling and its uses across personalized and population healthcare, while also covering the advent of new technology fields, such as surgical metabonomics. In addition, the text presents specific examples of where this technology has been used clinically and with efficacy, pointing towards a framework and protocol for usage as it hits the clinical mainstream. Translates the conjunction of new surgical tools for intraoperative, real-time, metabolite evaluation and direct analysis of biofluid samples into novel options for augmented clinical decision-making Discusses longitudinal sampling from individual patients for stratified medicine Covers high resolution analytical spectroscopy and sophisticated computational modelling for prediction of adverse reactions in critical care scenarios, prognostic evaluation of cancer from biofluidism, and prognostic prediction of metabolism or response of patients to pharmaceutical interventions Encapsulates recent technology options for broader population profiling considerations, in particular, the metabolome-wide association studies (MWAS) that aid the translational researcher in identifying metabolic patterns associated with disease Foreword written by Professor Dame Sally Davies who is the Chief Medical Officer for England

Cardiac Tumor Pathology

Author: Cristina Basso
Publisher: Springer Science & Business Media
ISBN: 162703143X
Size: 44.13 MB
Format: PDF
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Cardiac tumors were once a nosographic entity of scarce clinical interest because of the rarity and of the intrinsic diagnostic and therapeutic impossibilities, and were considered a fatal morbid entity. It has now become a topical subject due to advances in clinical imaging (echo, magnetic resonance, computed tomography) as well as innovation in technologies of in-vivo diagnosis. Cardiac Tumor Pathology presents a spectacular example of these advances with clinico-pathologic correlations. This timely volume covers history, epidemiology, demographics, clinical diagnosis, pathology, imaging by echo, CT and MRI of both benign and malignant cardiac tumors, either primary or secondary. Chemotherapy of malignant neoplasms is also addressed. Special emphasis is given to clinico-pathologic correlations. With all chapters written by experts in their fields, this volume will serve as a useful resource for physicians dealing with, and interested in, this special branch of cardiac oncology and will represent a useful guide for pathologists, clinicians, cardiologists, cardiac surgeons, and radiologists as well as for postgraduate students training in these areas.